Skip To Main Content
Haithem Barbour on Muck Rack

Haithem Barbour

As seen in: Nature
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work. Claim your profile

Get in touch with Haithem

Contact Haithem, search articles and posts on X, monitor coverage, and track replies from one place.

Learn more about Muck Rack

Actions

Share this page

Is this you?

As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile

Articles

Polycomb group-mediated histone H2A monoubiquitination in epigenome regulation and nuclear processes

|
By Michael J. Hendzel, El Bachir Affar, Haithem Barbour, Salima Daou
| Nature Verified
Abstract Histone posttranslational modifications are key regulators of chromatin-associated processes including gene expression, DNA replication and DNA repair. Monoubiquitinated histone H2A, H2Aub (K118 in Drosophila or K119 in vertebrates) is catalyzed by the Polycomb group (PcG) repressive complex 1 (PRC1) and reversed by the PcG-repressive deubiquitinase (PR-DUB)/BAP1 complex.
Open in Who Shared Issue with article?

Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1

|
By Salima Daou, Haithem Barbour, Oumaima Ahmed, Louis Masclef
| Nature Verified
Because the interaction between BAP1 and ASXL2 is important for their stability and tumor suppression33, we sought to investigate the potential role of ubiquitination in coordinating BAP1/ASXL2 stability and function. First, we co-transfected Myc-ASXL2 in HEK293T cells with HA-Ub and Flag-BAP1, and immunoprecipitated (IP) ASXL2 protein to detect its ubiquitination state. Immunoblotting with anti-HA (Ub) revealed a distinct ASXL2 protein band suggesting its monoubiquitination (Fig. 1c).
Open in Who Shared Issue with article?
See all 2 articles