Haiyang Qin

Biological and Medical Applications of Materials and InterfacesJanuary 30, 2025 * Lidong Wu State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Fisheries Engineering Institute, Chinese Academy of Fishery Sciences, Beijing 100141, China College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, P. R.

Fidelity estimation is an important technique for evaluating prepared quantum states in noisy quantum devices. A recent theoretical work proposed a frugal approach called neural quantum fidelity estimation (NQFE) [X. Zhang et al., Phys. Rev. Lett. 127, 130503 (2021).].

Highlights • Over 100 mutations were selected for analyses on their infectivity and antigenicity • The dominant D614G itself and combined with other mutations are more infectious • Ablation of both N331 and N343 glycosylation at RBD drastically reduced infectivity • Ten mutations such as N234Q, L452R, A475V, and V483A was markedly resistant to some mAbs Summary The spike protein of SARS-CoV-2 has been undergoing mutations and is highly glycosylated.