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Haiyin Yang on Muck Rack

Haiyin Yang

As seen in: Wiley Online Library, Royal Society of Chemistry
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Articles

Ugi Reaction-Derived Ionizable Lipids with Cyclic Tertiary Amine Heads Enable Spleen-Targeted mRNA Delivery

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By Xiaoyin Liu, Haiyin Yang, Shuxiang Wang, Yashuai Wang
| Royal Society of Chemistry Verified
Ugi Reaction-Derived Ionizable Lipids with Cyclic Tertiary Amine Heads Enable Spleen-Targeted mRNA Delivery Lipid nanoparticles (LNPs) have become an important platform for nucleic acid delivery. However, there is a nonnegligible challenge for LNPs mediated delivery to non-hepatic organs and specific cell types. As a key component of LNPs, ionizable lipids were rationally designed by adjusting the LNPs property to achieve organ targeted delivery.
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Spatiotemporal‐Controlled NIR‐II Immune Agonist Sensitizes Cancer Immunotherapy

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By Shuai Guo, Dongsheng Tang, Mengjie Zhang, Haiyin Yang
| Wiley Online Library Verified
The integration of nanomedicine and immunotherapy has presented a promising opportunity for treatment of cancer and diverse diseases. However, achieving spatiotemporal controllable immunotherapy with excellent efficacy and safety performances remains a significant challenge. This study develops a biodegradable near-infrared-II (NIR-II) photothermal response polymer nanoparticle (PTEQ) system.
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