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Articles

Antibodies to FXa and thrombin in patients with SLE differentially regulate C3 and C5 cleavage

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By Thomas McDonnell, Raj Amarnani, Charis Pericleous, Hajar Jbari
| bmj.com
Systemic Lupus Erythematosus Antibodies, Antiphospholipid Autoantibodies WHAT IS ALREADY KNOWN ON THIS TOPIC Currently, it is known that complement and coagulation interact, and that anti activated factor X (aFXa) and anti (a)Thr antibodies are present in both SLE and antiphospholipid syndrome. aFXa and aThr have been shown to have effects on calcium flux, but their role in complement activation is unknown.
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