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Hallur Reynisson on Muck Rack

Hallur Reynisson

As seen in: Nature
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Articles

Culture media alter retinal organoid physiology promoting AAV transduction and retinal ganglion cell survival

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By Michelle O’Hara-Wright, Benjamin Lim, Melissa M Mangala, Vivienne M. Kaiser, Emilie Wong, Deborah Aubin, Hallur Reynisson, Nader Aryamanesh, João Paulo, Stefano Palomba, Mehdi Mirzaei, Samantha L. Ginn, Anai Gonzalez-Cordero, Victoria Nemeruck, Fatemeh Doroudian, Otilia P. Y. Chan
| Nature Verified
Abstract Human iPSC-derived retinal organoids offer a human-relevant platform for inherited retinal disease (IRD) gene therapy, yet robust AAV transduction in vitro remains challenging. Here we show that culture in BrainPhys™ (BP) medium markedly enhances AAV-mediated gene delivery. Brief BP exposure during the transduction window improves uptake, whereas continuous BP culture yields the strongest effects, indicating contributions from acute entry processes and longer-term cellular remodelling.
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Mitf Links Neuronal Activity and Long-Term Homeostatic Intrinsic Plasticity

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By Hallur Reynisson, Anna Thora Petursdottir, Thor Eysteinsson, Eirikur Steingrimsson
| eneuro.org
Research ArticleResearch Article: New Research, Neuronal Excitability Diahann A. M. Atacho, Hallur Reynisson, Anna Thora Petursdottir, Thor Eysteinsson, Eirikur Steingrimsson and Petur Henry Petersen eNeuro 19 March 2020, 7 (2) ENEURO.0412-19.2020; DOI: https://doi.org/10.1523/ENEURO.0412-19.2020 Abstract Neuroplasticity forms the basis for neuronal circuit complexity and differences between otherwise similar circuits.
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