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Hamaira Liaqat on Muck Rack

Hamaira Liaqat

As seen in: Taylor & Francis Online
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Articles

Polyplex-Based Nonviral Gene Delivery: Recent Advances in Polymer Design, Mechanisms, and Therapeutic Applications

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By Huma Hameed, Syed Ahmad, Hamaira Liaqat
| Taylor & Francis Online
ABSTRACT Polyplexes are versatile, efficient nonviral vectors for gene-based therapies and offer safer alternatives to conventional viral delivery systems. Delivering nucleic acids, including DNA, RNA, and siRNA, remains challenging because of limited stability, cellular uptake, and intracellular trafficking. Formed through spontaneous electrostatic interactions between cationic polymers and negatively charged genetic material, polyplexes can help overcome these barriers.
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