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Han-Ying Cheng

As seen in: Cell Reports Medicine
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Out-of-frame CBX3::ALK fusion drives ALK activation and therapy response

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By Jen-Fan Hang, Yu-Shuen Tsai, Sin-Ying Lin, Jie-Hong Song, Chih-Hung Chung, Muh-Hwa Yang, Han-Ying Cheng
| Cell Reports Medicine Verified
Results A 50 year-old Taiwanese male patient was diagnosed with stage IIIC malignant melanoma on the right sole in November 2020 and underwent surgical treatment. Initial genetic testing by Sanger sequencing revealed no BRAF mutation, but a KIT p.S451Y variant of undetermined significance was detected. The patient received adjuvant pembrolizumab for 1 year. However, in August 2022, multiple distant metastases were discovered in the lung, liver, stomach, and bone.
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