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This review updates the 2016 systematic review of LN in Africa (9) by including newer cases published between 2016 and 2024. Our findings reinforce LN as a major cause of CKD and mortality in African SLE patients and provide additional evidence of regional disparities in presentation and outcomes. Our analysis of lupus nephritis (LN) cases across Africa demonstrates patterns that both confirm and extend existing global understanding of this condition.
Case presentation A 51-year-old Ugandan man from the tribe of Ankole who had no documented chronic illness visited an outpatient department at Kampala International University-Teaching Hospital (KIU-TH) in Ishaka-Bushenyi in February 2024 in a wheelchair. His main complaint was lower limb weakness for about 2 months. The weakness was progressively worsening over days, making him walk at a slow pace with an abnormal gait and often times needing support.
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