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Articles by Hang He
WorkRover: Scaling Long-Horizon Cowork Agent Training Via Recursive Environment Evolution
Published on Oct 13 · Submitted by Bench is all you need on Oct 14 · Nex AGI Abstract Scaling interactive environments is important for training long-horizon agents through reinforcement learning. These environments often require further testing and refinement after initial generation, and correcting defects in a task may also require updating its work context and verifier.
BayesJudge: Uncertainty-Aware Bayesian Meta-Evaluation of Human and LLM Judgments
AI evaluation pipelines often produce conflicting judgments rather than clean labels. In pairwise LLM evaluation, this conflict is especially visible: disagreement can arise from ambiguous items, underspecified rubrics, heterogeneous or unstable human raters, or an LLM judge whose verdict changes when the response order is swapped.
A pangenome of tetraploid wheat reveals the genetic architecture underlying domestication and genomic diversity for breeding
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Abstract Tetraploid wheat (Triticum turgidum L., BBAA), a key pasta crop, serves as an untapped genetic resource with rich genomic diversity for hexaploid bread wheat improvement. Here we de novo assembled 12 genomes spanning all 10 recognized tetraploid wheat (genome BBAA) subspecies, and a graph-based pangenome was constructed.
By Jianxin Bian, Guang Yang, Dong Xu, Yan Zhang, Guifen Zhang, Zhen Qin, Shuangxing Zhang, Yiqiao Wang, Mengmeng Jiang, Yan Pan, Bin Chen, Fangyu Liu, Yuqing Lu, Shuai Dominique Ding, Jiabo Wang, Can Yuan, Yongming Chen, Shoucheng Liu, Hang He, Shuai Wang, Qidi Zhu, Shisheng Chen, Qing Sang, Xing Wang Deng, Hude Mao, Xiaojun Nie, Baoxing Song, Yanzhe Jia
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Nature
Verified
DNA hypomethylation enables the transcriptional repressor SlSPL-CNR to control fruit flavor ester biosynthesis
Abstract Reduction of DNA methylation has traditionally been associated with gene activation. Here, we show that DNA hypomethylation permits the binding of a transcriptional repressor, leading to gene silencing. In tomato, the SQUAMOSA PROMOTER BINDING PROTEIN-LIKE TF SlSPL-CNR exhibits methylation-sensitive DNA binding and preferentially occupies unmethylated GTACGG motifs.
Discovery and heterologous reconstitution of a plant noncanonical quasi-circadian gene regulatory network
Keywords plant circadian clock heterologous reconstitution strawberry plant immunity Get full text access Log in, subscribe or purchase for full access. References 1. Nohales, M.A. ∙ Kay, S.A. Molecular mechanisms at the core of the plant circadian oscillator Nat. Struct. Mol. Biol. 2016; 23:1061-1069 2. Xu, X.D. ∙ Yuan, L. ∙ Yang, X. ... Circadian clock in plants: Linking timing to fitness J. Integr. Plant Biol. 2022; 64:792-811 3. Petersen, J. ∙ Rredhi, A. ∙ Szyttenholm, J. ...
Telomere-to-telomere genome assemblies and population resequencing of diploid and allotetraploid peanut varieties
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Abstract Peanut (Arachis hypogaea L.) is a globally significant leguminous oil crop.
By Jianxin Bian, Yilin Zhang, Shuai Dominique Ding, Kui Li, Yu Guan, Guoliang Zhou, Jihua Li, Vanika Garg, Yuanyuan Cui, Yuan Lv, Annapurna Chitikineni, Tianyu Li, Liangqiong He, Chuanzhi Zhao, Xingjun Wang, Ronghua Tang, Liangsheng Zhang, Xing Wang Deng, Rajeev K Varshney, Hang He, Xiaoqin Liu, Haosong Guo, Qingjing Meng
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Nature
Verified
Haplotype-resolved, gap-free genome assemblies provide insights into the divergence between Asian and European pears - Nature Genetics
Abstract Pears (Pyrus spp.) are self-incompatible crops with broad genetic diversity. High heterozygosity and technical limitations result in gaps within reference genomes. Our study presents the telomere-to-telomere, haplotype-resolved genomes of a representative Asian pear ‘Dangshansuli’ (Pyrus bretschneideri) and a European pear ‘Max Red Bartlett’ (Pyrus communis).
Haplotype-resolved T2T genome assembly of the pear cultivar ‘Danxiahong’ - Scientific Data
Abstract Pear (Pyrus L) is one of the most significant fruit crops globally, recognized for its substantial economic value and potential health benefits. ‘Danxiahong’ is an elite pear cultivar in the north of China, characterized by its flushed fruit skin and excellent inner quality. In this study, we utilized PacBio HiFi long reads, Hi-C reads and second-generation sequencing data to assemble the genome of ‘Danxiahong’.
Two haplotype-resolved telomere-to-telomere genome assemblies of Xanthoceras sorbifolium - Scientific Data
Abstract Yellowhorn (Xanthoceras sorbifolium) is widely used in northern China for landscaping, desertification control, and oil production. However, the lack of high-quality genomes has hindered breeding and evolutionary studies. Here, we present the first haplotype-resolved, telomere-to-telomere (T2T) yellowhorn genomes of PBN-43 (white single-flowered) and PBN-126 (white double-flowered) using PacBio HiFi and Hi-C data.
Tungsten Sulfide with Expanded Interlayer for Long‐Life and Wide‐Temperature Mg‐Ion Batteries
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202503917-sup-0001-SuppMat.docx1.8 MB Supporting Information References 1, , Chem. Mater. 2010, 22, 587. 2, , , , , , , , , , , Nat. Mater. 2023, 22, 225. 3, , , J. Alloy Compd. 2019, 775, 1251. 4, , , Nanoscale 2014, 6, 9889. 5, , , , , , , , , J. Mater. Chem. A 2019, 7, 946. 6, , , , , Mater. Chem. Phys. 2020, 246, 122832. 7, , , , , , , J. Mater. Chem. A 2013, 1, 14548. 8, , , , , J. Electrochem. Sci.
A telomere-to-telomere genome assembly coupled with multi-omic data provides insights into the evolution of hexaploid bread wheat - Nature Genetics
Abstract The complete assembly of vast and complex plant genomes, like the hexaploid wheat genome, remains challenging. Here we present CS-IAAS, a comprehensive telomere-to-telomere (T2T) gap-free Triticum aestivum L. genome, encompassing 14.51 billion base pairs and featuring all 21 centromeres and 42 telomeres. Annotation revealed 90.8 Mb additional centromeric satellite arrays and 5,611 rDNA units.
Chromosome-scale genome assembly of Zoysia japonica uncovers cold tolerance candidate genes - Scientific Data
Abstract Zoysiagrass stands out as a crucial native turfgrass due to its exceptional abiotic stress tolerance, extensive adaptability, and high ornamental value. In this study, we generated a high-quality chromosome-level genome assembly of Compadre (COM) zoysiagrass, leveraging PacBio SMRT sequencing and Hi-C scaffolding technologies.
Depicting pathogenesis of osteomyelitis by single cell RNA-sequencing and an involvement of Morrbid in the autoinflammatory disease
Abstract Autoinflammatory diseases (AIDs) are defined as abnormal activation of the innate immune system leading to spontaneous and uncontrolled inflammation. The AIDs affect bone tissue and lead to chronic recurrent multifocal osteomyelitis (CRMO). However, the etiology and treatment of CRMO remain elusive. A mouse strain, Pstpip2cmo/cmo (cmo: chronic multifocal osteomyelitis), exhibits phenotypic characteristics similar to human CRMO.
Promoter capture Hi-C identifies promoter-related loops and fountain structures in Arabidopsis - Genome Biology
The mutant and WT were established on the Columbia-0 (Col-0) background. The T-DNA insertional mutant used in this study, atxr3 mutant (sdg2, SALK_021008), was previously described [44]. The syn4 mutant (SALK_130085) was obtained from the European Arabidopsis Stock Centre (NASC, https://arabidopsis.info).
An Ultra-Sensitive and Recyclable FET-Type Toxic Gas Sensor Based on WTe2 Monolayer
An Ultra-Sensitive and Recyclable FET-Type Toxic Gas Sensor Based on WTe2 Monolayer Field-effect-transistor (FET)-type gas sensors have attracted a surge of research interest due to their low power dissipation and exceptional sensitivity. However, theoretical explorations into their sensing capability and underlying mechanism remain scare.
Computing hematopoiesis plasticity in response to genetic mutations and environmental stimulations
Abstract Cell plasticity (CP), describing a dynamic cell state, plays a crucial role in maintaining homeostasis. Single-cell-omics datasets provide unprecedented resource to empowers analysis on CP. Hematopoiesis offers fertile opportunities to develop quantitative methods for understanding CP with rich supports from experimental ground-truths.
Two telomere-to-telomere gapless genomes reveal insights into Capsicum evolution and capsaicinoid biosynthesis - Nature Communications
Abstract Chili pepper (Capsicum) is known for its unique fruit pungency due to the presence of capsaicinoids. The evolutionary history of capsaicinoid biosynthesis and the mechanism of their tissue specificity remain obscure due to the lack of high-quality Capsicum genomes. Here, we report two telomere-to-telomere (T2T) gap-free genomes of C. annuum and its wild nonpungent relative C. rhomboideum to investigate the evolution of fruit pungency in chili peppers.
An Insight in the Viscosity-Temperature Property of CaO‐SiO2‐Al2O3‐Based Slag Systems from Melt Structure
Conflict of Interest The authors declare no conflict of interest. References 1 , , , , , , , , , , , , , , Sci. Adv. 2020, 39, abb0413. 2 , , , , , , , J. Eur. Ceram. Soc. 2020, 40, 2179. 3 , , , Cem. Concr. Res. 2020, 138, 106231. 4 , , , , , , , , J. Cleaner Prod. 2020, 255, 120286. 5 , , , , , J. Non-Cryst. Solids 2022, 585, 121545. 6 , , , , , , J. Non-Cryst. Solids 2022, 596, 121865. 7 , , , ISIJ Int. 2021, 61, 745. 8 , , , , , Ceram. Int. 2021, 47, 33483. 9 , , , , , , Steel Res. Int. 2021, 92, 2000531.
Modeling and Numerical Computation of the Longitudinal Non-Linear Dynamics of High-Speed Elevators
1. Introduction The increase in high-rise buildings and the adoption of high-speed and ultra-high-speed elevators have heightened the awareness of elevator system vibrations. When the running speed reaches or exceeds 6 m / s , it is considered a high-speed elevator. Components of high-speed elevators, such as the mass of the car and counterweight and wire rope length, contribute to the low natural frequency and dense frequency distribution of the elevator system.
Time series single-cell transcriptional atlases reveal cell fate differentiation driven by light in Arabidopsis seedlings - Nature Plants
Abstract Light serves as the energy source for plants as well as a signal for growth and development during their whole life cycle. Seedling de-etiolation is the most dramatic manifestation of light-regulated plant development processes, as massive reprogramming of the plant transcriptome occurs at this time.
Photochemical Transformation of Dissolved Organic Matter in Surface Water Augmented the Formation of Disinfection Byproducts
Download Hi-Res ImageDownload to MS-PowerPointCite This:Environ. Sci. Technol. 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
Design of Carbazole-based Platinum Complexes with Steric Hindrance for Efficient Organic Light-emitting Diodes
Design of Carbazole-based Platinum Complexes with Steric Hindrance for Efficient Organic Light-emitting Diodes The construction of platinum complexes with high steric hindrance is expected to suppress triple-triplet annihilation and π-π stacking to achieve high-performance organic light-emitting diodes (OLEDs) with low efficiency roll-off.
Cooperative progression of colitis and leukemia modulated by clonal hematopoiesis via PTX3/IL-1β pro-inflammatory signaling
Abstract Clonal hematopoiesis (CH) is suggested as an important risk factor for all-cause mortality and multiple chronic diseases including hematological neoplasms, cardiovascular diseases, and potentially a spectrum of autoimmune or immune-deficiency diseases. Mutations in TET2 are one of the first identified, most important and prevalent genetic drivers of CH. However, cooperative factors and mechanisms underlying TET2-deficiency related CH (TedCH) remain largely unknown.
Mechanism of Crack Propagation during Hot‐Rolling Process of a Medium‐Carbon 40Cr Alloy Steel
Abstract In this work, the mechanism of crack propagation during hot-rolling process of a typical medium-carbon 40Cr alloy steel is investigated by cracks characterization, thermodynamic calculation, and confocal laser scanning microscopy (CLSM). The depth of cracks is about 2.5 mm and its length along with rolling direction can even reach 2000–3000 mm.
Identification of Genes Associated with Liver Metastasis in Pancreatic Cancer Reveals PCSK6 as a Crucial Mediator
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Effects of Yeast Culture Supplementation on Growth Performance, Nutrient Digestibility, Blood Metabolites, and Immune Response in Geese
Search Type Submit to this Journal Review for this Journal Edit a Special Issue Article Menu /ajax/scifeed/subscribe share announcement question_answer thumb_up ... textsms ... Need Help? Support Find support for a specific problem in the support section of our website. Get Support Feedback Please let us know what you think of our products and services. Give Feedback Information Visit our dedicated information section to learn more about MDPI.
Effect of yeast culture supplementation on blood characteristics, body development, intestinal morphology, and enzyme activities in geese
ORIGINAL ARTICLE Jie Zhang and Yancong Yuan contributed equally to this study. Abstract The objective of this experiment is to evaluate the effects of yeast culture (YC) supplementation on blood characteristics, body size, carcass characteristics, organ weights, intestinal morphology, and enzyme activities. Five groups of geese were randomly assigned to five dietary treatments: the basal diet (control) and basal diets plus 0.5%, 1.0%, 2.0%, or 4.0% YC.
A high-quality genome assembly highlights rye genomic characteristics and agronomically important genes
Abstract Rye is a valuable food and forage crop, an important genetic resource for wheat and triticale improvement and an indispensable material for efficient comparative genomic studies in grasses. Here, we sequenced the genome of Weining rye, an elite Chinese rye variety. The assembled contigs (7.74 Gb) accounted for 98.47% of the estimated genome size (7.86 Gb), with 93.67% of the contigs (7.25 Gb) assigned to seven chromosomes. Repetitive elements constituted 90.31% of the assembled genome.
Adsorption behaviour of carbon nanodots modulated by cellular membrane potential
Adsorption behaviour of carbon nanodots modulated by cellular membrane potential Carbon nanodots (CDs), as a kind of fluorescent nanomaterials, have attracted widespread attention for biomedical application. Since different cells possess different membrane potential, the influence of trans-membrane potential on the adsorption behaviour is required to be explored extensively.
Mechanistic studies on the Antibacterial Behavior of Ag Nanoparticles Decorated with Carbon dots bearing Different Oxidation Degrees
Mechanistic studies on the Antibacterial Behavior of Ag Nanoparticles Decorated with Carbon dots bearing Different Oxidation Degrees In this work, carboxylated carbon dots (C-CDs) with higher oxidation degrees or hydroxylated CDs (H-CDs) with lower oxidation degrees were applied to fabricate CDs capped silver nanoparticles (defined as C-CDs@AgNPs and H-CDs@AgNPs, respectively) via one step strategy. These two types of as prepared AgNPs possess similar size, morphology and surface charge.
Enhanced tumor targeting of cRGD peptide-conjugated albumin nanoparticles in the BxPC-3 cell line
Gemcitabine was got from Eli Lilly and Company (Indiana, USA). HSA (20%, 50 mL) was purchased from the Baxter AG (Vienna, Austria). cRGD (sequence: Arg-Gly-Asp-D-Tyr-Lys) was synthesized by Shanghai Gil Biochemistry Co., Ltd. (Shanghai, China); the purity was greater than 99.9%. Sulfo-SMCC (sulfosuccinimidyl-(4-N-maleimidomethyl)cyclohexane-1-carboxylate) was obtained from Thermo Fisher Scientific (Waltham, MA, USA). Normal saline (NS) was purchased from Shanghai Baxter Healthcare Co., Ltd.
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