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Hanguang Li

As seen in: Frontiers
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Articles

Cerebrospinal fluid mechanics across CNS barriers: from production, circulation, and clearance to mechanomedicine

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By Bei Deng, Yannan Zhao, Dezhong Peng, Xinglin Cheng, Hanguang Li, Tianen Zhan
| Frontiers
Abstract Background: Cerebrospinal fluid (CSF) is often framed as a transport medium, yet its motion and pressure dynamics impose continuous mechanical loading on central nervous system (CNS) barrier and interface systems. These cues span scales—from cilia-scale near-wall shear to craniospinal compliance-driven pulsatility—and may shape barrier phenotypes, immune programs, and clearance efficiency.
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