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Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism
1 Introduction Ventricular arrhythmias (VAs) are abnormal heart rhythms that originate from the ventricles, which are characterized primarily by disturbances in the ventricular electrical activation sequence, frequency, or rhythm. VAs that encompass premature ventricular contraction (PVC), ventricular tachycardia (VT), ventricular flutter (Vf), and ventricular fibrillation (VF) are common cardiac arrhythmias in clinical practice [1].
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