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Hanjun Dan

As seen in: Nature, BioRxiv, Dialnet - Universidad de La Rioja
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Articles by Hanjun Dan

Arginine Di-methylation of RIP3 safeguards necroptosis for intestinal homeostasis

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By Pan Zhao, Hanjun Dan, Yazhou Wang, Xin McRae Chen, Xiangling Jiang, Yao Shen, Dan Feng, Jiajia Wang, Zhiwei Yang, Jiasheng Zhao, Yingying Zhang, Mengying Wei, Jianyong Zheng, Wen Liu, Jian Qiao Zhang
| Nature Verified
Abstract Necroptosis, driven by RIP3, is critical for intestinal homeostasis but requires stringent regulation to prevent inflammatory pathology. While inhibitory checkpoints of RIP3 are known, mechanisms enabling its physiological activation remain unclear. We identify PRMT5-mediated symmetric di-methylation of RIP3 at arginine 479 (R479) serves as a gatekeeper specifically suppresses RIP1- but not ZBP1- driven necroptosis in intestinal epithelial cells (IECs).
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NDRG2 orchestrates circadian clock stability to suppress tumorigenesis and potentiate oxaliplatin response in colorectal cancer

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By Ruikai Li, Ruxin Ding, Hanjun Dan, Kunli Du, Gaozan Zheng, Siyuan Wang, Lili Duan, Pengfei Wang, Liangliang Shen, Lin Feng, Pan Zhao, Jiajia Wang, Dan Feng, Fengsu Wu, Ziting Zhou, Liaoran Niu, Weidong Wang, Xinyu Qiao, Jianting Yang, Fan Feng, Jianyong Zheng, Jian Zhang, Yumao Yang
| Nature Verified
Abstract Circadian disruption is linked to colorectal cancer (CRC) progression. We investigated the role of the tumor suppressor N-myc downstream-regulated gene 2 (NDRG2) in this context. Intestinal-specific Ndrg2 knockout exacerbated colorectal tumorigenesis in mice under circadian disruption. We identified NDRG2 as a novel stabilizer of the core clock protein Circadian Locomotor Output Cycles Kaput (CLOCK).
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Prognostic value of dynamic changes of pre‑ and post‑operative tumor markers in colorectal cancer

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By Guangming Ren, Gaozan Zheng, Hanjun Dan, Kunli Du
| Dialnet - Universidad de La Rioja
Ayuda Buscar en la ayuda Buscar en la ayuda Prognostic value of dynamic changes of pre‑ and post‑operative tumor markers in colorectal cancer Guangming Ren [1] ; Gaozan Zheng [1] ; Kunli Du [1] ; Hanjun Dan [1] ; Xinyu Dou [1] ; Lili Duan [1] ; Zhenyu Xie [1] ; Liaoran Niu [1] ; Ye Tian [1] ; Jianyong Zheng [1] ; Fan Feng [1] ; Zhangfeng Dang [2] [1] Department of Gastrointestinal Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, China [2] Department of General Surgery, Air...
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Arginine Di-methylation of RIPK3 Safeguards Necroptosis for Intestinal Homeostasis

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By Jian Zhang, Pan Zhao, Yazhou Wang, Hanjun Dan
| BioRxiv
Abstract The necroptosis mediated by RIPK3 is stringently regulated for intestinal homeostasis. Here we found that mice lacking Prmt5 (Protein arginase methyltransferase 5) in intestinal epithelial cells (IECs) caused premature death with IECs necroptosis, villus atrophy and loss of Paneth cells.
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