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Articles by Hanlin Lu
Cell-free DNA methylation biomarkers for the early detection and tumor burden monitoring of gastric cancer
Abstract Development of sensitive biomarkers is required to achieve early detection and tumor burden monitoring in gastric cancer (GC). We performed genome-wide methylation sequencing on 78 tissue and 241 plasma samples from 171 GC patients and 114 healthy controls from two independent clinical centers.
Acoustoelectric control of optoelectronic anisotropy for reconfigurable polarimetry
Abstract Harnessing light polarization provides a powerful degree of freedom for optical communications, imaging, and sensing. Two-dimensional (2D) anisotropic semiconductors have emerged as a promising platform for miniaturized on-chip polarimetry; however, their polarization responses remain constrained by intrinsic crystal symmetries and static device geometries, limiting functional tunability.
Macrophage Gsα promotes NLRP3 stability and its intervention attenuates abdominal aortic aneurysm in male mice
Abstract Abdominal aortic aneurysm (AAA) is a life-threatening degenerative aortic disease that primarily affects older individuals. While macrophages are central to AAA pathogenesis, the regulatory role of the stimulatory G protein α subunit (Gsα) in macrophages remains poorly understood. In this study, using an Angiotensin Ⅱ-induced abdominal aortic aneurysm model on male mice, we demonstrate that macrophage-specific Gnas deficiency significantly attenuates AAA progression.
Macrophage junctional adhesion molecule-like (JAML) protein promotes NLRP3 inflammasome activation in the development of atherosclerosis - Cell Death & Differentiation
Abstract Inflammation plays a crucial role in the progression of atherosclerosis. Junctional adhesion molecule-like protein (JAML), a type-I transmembrane glycoprotein, activates downstream signaling pathways. However, the precise role of macrophage-derived JAML in inflammation and atherosclerosis remains unclear.
ZFP36 Regulates Vascular Smooth Muscle Contraction and Maintains Blood Pressure
1 Introduction Hypertension is a common chronic disease impacting 1.4 billion people worldwide, accounts for 10.4 million deaths each year.[1] Hypertension causes severe damage to many organs, including the brain, heart, and kidneys, and it is the main risk factor for stroke and coronary artery disease. Thus, the mechanisms underlying hypertension should be urgently explored, and novel therapeutic targets and strategies should be developed.
Endothelial Sp1/Sp3 are essential to the effect of captopril on blood pressure in male mice - Nature Communications
Abstract Endothelial dysfunction represents a major cardiovascular risk factor for hypertension. Sp1 and Sp3 belong to the specificity protein and Krüppel-like transcription factor families. They are ubiquitously expressed and closely associated with cardiovascular development. We investigate the role of Sp1 and Sp3 in endothelial cells in vivo and evaluate whether captopril, an angiotensin-converting enzyme inhibitor (ACEI), targets Sp1/Sp3 to exert its effects.
Recent progress in morphology optimization in perovskite solar cells
Recent progress in morphology optimization in perovskite solar cells Perovskite solar cell technology has passed through a phase of unprecedented growth in the efficiency scale from 3.8% to above 24% within a decade. This technology has drawn tremendous research interest. It has been observed that performances of perovskite-based solar cells are extremely dependent on the morphology and crystallinity of the perovskite layer.
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