Hanna Kaisa Vikkula on Muck Rack

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Type I and type III interferon receptor knockout chickens: Novel models for unraveling interferon dynamics in influenza infection

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By Romina Klinger, Christian Zenner, Mohanned Alhussien, Hanna Kaisa Vikkula
| biorxiv.org
Abstract The rapid cross-species transmission of highly pathogenic avian influenza presents a significant zoonotic threat. Elucidating the avian interferon (IFN) system, the primary antiviral defense in chickens, is critical for controlling the virus at its source and preventing its spillover into humans and other species. We engineered type I (IFN-α/β) and type III (IFN-λ) IFN receptor knockout chickens to dissect the role of IFNs in viral infections.
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