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Hanna Schwaemmle on Muck Rack

Hanna Schwaemmle

As seen in: BioRxiv
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Articles

CRISPR screen decodes SWI/SNF chromatin remodeling complex assembly

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By Hanna Schwaemmle, Hadrien Soldati, Mylene Docquier, Alexandre Hainard
| BioRxiv
Abstract The SWI/SNF (or BAF) complex is an essential chromatin remodeler that regulates DNA accessibility at developmental genes and enhancers. SWI/SNF subunits are among the most frequently mutated genes in cancer and neurodevelopmental disorders. These mutations are often heterozygous loss-of-function alleles, indicating a dosage-sensitive role for SWI/SNF subunits in chromatin regulation.
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