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Hanniel O. Uwadia on Muck Rack

Hanniel O. Uwadia

As seen in: Nature
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Articles

A dual-pathway architecture for stress to disrupt agency and promote habit - Nature

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By Abigail Yu, Kayla y Lim, Alcino J. Silva, Avishek Adhikari, Hanniel O. Uwadia, Fernando MCV Reis
| Nature Verified
Abstract Chronic stress can change how we learn and, thus, how we make decisions1,2,3,4,5. Here we investigated the neuronal circuit mechanisms that enable this. Using a multifaceted systems neuroscience approach in male and female mice, we reveal a dual-pathway, amygdala–striatal neuronal circuit architecture by which a recent history of chronic stress disrupts the action–outcome learning underlying adaptive agency and promotes the formation of inflexible habits.
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