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Hans-Dieter Barth

As seen in: Wiley Online Library, BioRxiv
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Articles

Single‐Molecule FRET‐Tracking of InlB‐Activated MET Receptors in Living Cells

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By Yunqing Li, Marina S. Dietz, Hans-Dieter Barth, Hartmut H. Niemann
| Wiley Online Library Verified
1 Introduction The transmembrane receptor MET, also known as hepatocyte growth factor receptor (HGFR), belongs to the class of receptor tyrosine kinases (RTKs) and plays a central role in regulating key cellular functions, including proliferation, migration, morphogenesis, and tissue regeneration.[1-3] Dysregulation of MET is associated with various diseases, including cancer.[4-6] MET is activated upon binding of its physiological ligand, hepatocyte growth factor/scatter factor (HGF/SF),[7,...
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Single-molecule FRET-tracking of InlB-activated MET receptors in living cells

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By Yunqing Li, Marina S. Dietz, Hartmut H. Niemann, Hans-Dieter Barth
| BioRxiv
Abstract The activation of transmembrane receptors through the binding of external ligands initiates information transfer across the cell membrane. Understanding these processes requires observations in living cells. Given the heterogeneity and lack of synchronization of such events demands for single-molecule experiments that can resolve distinct sub-populations.
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