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Hans Jefferson C. Ng

As seen in: Nature
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Articles

Reprogramming the Rossmann fold signature motif creates orthogonal redox biocatalysts

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By Yu Ping, Jin Kim, Minh-Anh Dinh, Emma Luu, Suphanida Worakaensai, Shiding Zhang, William Black, Emma Monge, Hans Jefferson C. Ng, Yulai Zhang, Youtian Cui, Edward King, Justin B. Siegel, Sean Perea
| Nature Verified
Abstract Biological reducing power is carried by nicotinamide adenine dinucleotide (phosphate) (NAD(P)/H), which supports cellular functions and cannot be specifically directed to engineered metabolic pathways. Nicotinamide mononucleotide (NMN(H)) has emerged as an orthogonal redox cofactor to address this.
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A sequence motif enables widespread use of noncanonical redox cofactors in natural enzymes

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By Emma Luu, Vincent Martin, William Black, Shiding Zhang, Jin-Kwang Kim, Banumathi Sankaran, Andre Tran, Ryan Hayes, Justin B. Siegel, Feng Qiao, Samer Saleh, Ning-Hsiang Hsu, Hans Jefferson C. Ng
| Nature Verified
Abstract Noncanonical redox cofactors (NRCs) are low-cost alternatives to the natural redox cofactors nicotinamide adenine dinucleotide (NAD+) and nicotinamide adenine dinucleotide phosphate (NADP+) for biomanufacturing, offering exquisite electron-delivery control, yet their adoption is limited by the scarcity of compatible enzymes. Screening the aldehyde dehydrogenase (ALDH) family, we identified a conserved RH/QxxR motif that enables widespread NRC activity among natural enzymes.
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