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Multimodal analysis stratifies genetic susceptibility and reveals the pathogenic mechanism of kidney injury in diabetic nephropathy
Keywords diabetic nephropathy genome-wide association study multimodal analysis TCN2 Introduction Diabetic nephropathy (DN) is the most common type 2 diabetes (T2D) microvascular complication and the leading global cause of end-stage kidney disease.1 DN has significant familial clustering and SNP heritability,2,3 yet its specific genetic risks remain largely unknown.
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