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Hanying Wu on Muck Rack

Hanying Wu

As seen in: Taylor & Francis Online
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Articles

Structure-guided discovery and evaluation of an EGFR L858R-targeting peptide with antiproliferative activity against ovarian cancer cells

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By Yinxing Zhu, Hanying Wu, Xiaohao Liu
| Taylor & Francis Online
Abstract EGFR L858R is an activating mutation associated with aberrant EGFR signalling, and molecules capable of recognising this mutant remain of research interest. In this study, a virtual peptide library containing 59 319 heptapeptides was screened against the EGFR L858R crystal structure, leading to the identification of four peptides with favourable predicted binding ability.
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Full article: Discovery of novel dual-targeting inhibitors against PLK1-PBD and PLK4-PB3: structure-guided pharmacophore modelling, virtual screening, molecular docking, molecular dynamics simulation, and biological evaluation

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By Changhao Zhao, Hanying Wu, Huajing Liu, Hui Dong
| Taylor & Francis Online
Abstract Aberrant expression of PLK1 and PLK4 is closely associated with tumourigenesis, and their simultaneous inhibition can effectively suppress tumour proliferation. In this study, we successfully identified peptide inhibitors (Peptides 1–5) capable of simultaneously targeting PLK1-PBD and PLK4-PB3 via pharmacophore-based virtual screening. Binding affinity analyses demonstrated that all candidate peptides exhibited nanomolar binding affinity for both targets.
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Plasmon-Driven N2 Photofixation in Pure Water over MoO3-x Nanosheets under Visible to NIR Excitation

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By Hanying Wu, Xiao Li, Yao Cheng, Yi-Hong Xiao
| Royal Society of Chemistry Verified
Plasmon-Driven N2 Photofixation in Pure Water over MoO3-x Nanosheets under Visible to NIR Excitation Photochemical N2 fixation offers a promising route for the activation and transformation of inert nitrogen molecules to generate useful chemicals under mild conditions by using solar energy.
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