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Haohao Yin

As seen in: Nature, Cell Reports Medicine
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Articles

LIFUS-driven engineered bacteria reprogram immunosuppressive niches via mechano-NOTCH signaling

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By Lizhou Lin, XIAO LI, Wenyun Guo, Jirong Xie, Xiaolong Li, Xin Yuan Guan, Haohao Yin, Huixiong Xu, Chongke Zhao
| Cell Reports Medicine Verified
Keywords ultrasound mechanotransduction tumor microenvironment immunotherapy NOTCH pathway Introduction The tumor microenvironment (TME) imposes tightly interlinked physical and immunological barriers that fundamentally restrict therapeutic responses in solid tumors.1 Activated cancer-associated fibroblasts (CAFs) generate a dense, stiff extracellular matrix that increases interstitial pressure, impedes T cell infiltration, and limits drug penetration.2 Concurrently, hypoxia, acidosis, and...
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Transdermal microneedle-assisted ultrasound-enhanced CRISPRa system to enable sono-gene therapy for obesity - Nature Communications

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By Shaoyue Li, Jifeng Yu, Weichen Xu, Haohao Yin, Liping Sun
| Nature Verified
Abstract Obesity, a surging global health challenge, necessitates effective, accessible and innovative therapeutic models. Here we develop a spatiotemporally controllable microneedle (MN) drug delivery platform for sono-gene therapy to fight obesity.
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Design of a self-driven probiotic-CRISPR/Cas9 nanosystem for sono-immunometabolic cancer therapy - Nature Communications

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By Haohao Yin
| Nature Verified
Abstract Reprogramming the tumor immunosuppressive microenvironment is a promising strategy for improving tumor immunotherapy efficacy. The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9 system can be used to knockdown tumor immunosuppression-related genes.
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