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Haopu Dai

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SoxR-targeted redox vulnerability enables zinc-vitamin K3 therapy against Escherichia coli infection

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By Jie Feng, Runyu Chen, Liwen Zhang, Feng Liang, Hao Ke, Shihui Yu, Yuhang Bao, Haixia Zhang, Ruoxi Chen, Yiming Zhong, Zhixin Wu, Wu Wang, Guoqiang Tan, Jianghui Li, Xiaolong Hua, Haopu Dai
| Nature Verified
Abstract The rapid emergence of multidrug-resistant Escherichia coli highlights the urgent need for effective, host-compatible antibacterial strategies. Targeting bacterial redox homeostasis represents a promising non-antibiotic paradigm, yet rational synergistic approaches remain poorly defined. We show that zinc combined with vitamin K3 exhibits potent antibacterial activity against pathogenic E. coli, including enterotoxigenic ETEC K88, by selectively disrupting redox regulation.
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