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Haram Lee

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Articles

PDE3B as a multi-organ therapeutic node in the gut–liver axis of metabolic dysfunction-associated steatohepatitis

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By Youn Wook Chung, Da Hyun Lee, Haram Lee, Soohwan Oh, Jinhyuk Bhin, Ji-Hwan Ryu, June-Yong Lee, Yu Seol Lee, Chang-Yun Jeong, Yoseob Lee, Ji Yun Bang
| Nature Verified
Abstract Metabolic dysfunction-associated steatohepatitis (MASH) involves pathological crosstalk within the gut–liver axis, in which intestinal barrier dysfunction facilitates the translocation of microbial and dietary products and aggravates hepatic inflammation and fibrosis. Although phosphodiesterase 3B (PDE3B) is known to regulate metabolic and inflammatory processes, its role in gut–liver communication remains unclear.
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