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Hark Kyun Kim on Muck Rack

Hark Kyun Kim

As seen in: The BMJ, Science Magazine
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Articles

277 Establishment of novel syngeneic mouse gastric cell line models for CLDN18.2 CAR-T therapy

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By Min Ji Seo, Jin Hyeok Jeong, Hyeran Kim, Hark Kyun Kim
| The BMJ Verified
Abstract Background Only a few syngeneic mouse cell line models are available for gastric cancer. Methods We have established a cell line from an autochthonous gastric cancer formed in the stomach of a female genetically-engineered mouse (figure 1). Results This cell line recapitulated morphological and molecular features of human intestinal gastric cancer and readily formed a tumor when injected into syngeneic mice.
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Cell reprogramming using extracellular vesicles from differentiating stem cells into white/beige adipocytes

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By Youn Jung, Ji Suk Choi, Hark Kyun Kim, Yoonsuk Cho
| Science Magazine Verified
Abstract Stem cell–derived extracellular vesicles (EVs) offer alternative approaches to stem cell–based therapy for regenerative medicine. In this study, stem cell EVs derived during differentiation are developed to use as cell-free therapeutic systems by inducing tissue-specific differentiation. EVs are isolated from human adipose-derived stem cells (HASCs) during white and beige adipogenic differentiation (D-EV and BD-EV, respectively) via tangential flow filtration.
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