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Harmen J. Bussemaker on Muck Rack

Harmen J. Bussemaker

As seen in: Nature, BioRxiv
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Articles

Benchmarking DNA binding affinity models using allele-specific transcription factor binding data

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By Xiaoting Li, Lucas Melo, Harmen J. Bussemaker
| BioRxiv
Abstract Transcription factors (TFs) bind to DNA in a highly sequence-specific manner. This specificity can manifest itself in vivo at heterozygous loci as a difference in TF occupancy between the two alleles. When applied on a genomic scale, functional genomic assays such as ChIP-seq typically lack the statistical power to detect allele-specific binding (ASB) at the level of individual variants.
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Optimisation of TP53 reporters by systematic dissection of synthetic TP53 response elements

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By Max Trauernicht, Chaitanya Rastogi, Harmen J. Bussemaker, Stefano Giustino Manzo
| BioRxiv
Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website.
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In search of the determinants of enhancer-promoter interaction specificity

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By Joris van Arensbergen, Bas van Steensel, Harmen J. Bussemaker
| ncbi.nlm.nih.gov
Journal List HHS Author Manuscripts PMC4252644 Trends Cell Biol. Author manuscript; available in PMC 2015 Nov 1. Published in final edited form as: PMCID: PMC4252644 NIHMSID: NIHMS624501 Joris van Arensbergen 1 Division of Gene Regulation, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands Bas van Steensel 1 Division of Gene Regulation, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands Harmen J.
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