Harshanie Dasanayaka on Muck Rack

Harshanie Dasanayaka

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BatR: A novel regulator of antibiotic tolerance in Pseudomonas aeruginosa biofilms

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By Carlo Martins, Gerhard Saalbach, Ainelen Melanie Piazza, Harshanie Dasanayaka
| biorxiv.org
Abstract Pseudomonas aeruginosa is a multidrug-resistant opportunistic human pathogen. Chronic infections are associated with biofilms, conferring resistance to antibiotics and complicating treatment strategies. This study focuses on understanding the role of the uncharacterized gene PA3049, upregulated under biofilm conditions. In the context of P. aeruginosa biofilms, PA3049 plays a role in withstanding antimicrobial challenges both in vitro and in clinically validated infection models.
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