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Harshanna Badhesha on Muck Rack

Harshanna Badhesha

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Articles

How epigenetic clocks tick: unpacking the black box by deciphering biological pathways and transcriptomic signatures of accelerated aging

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By Thalida Em Arpawong, Steve Cole, Jung Ki Kim, Christopher Beam Verified, Eric Klopack, Kimberly D. Siegmund, Bharat Thyagarajan, Eileen M. Crimmins, Harshanna Badhesha
| Nature Verified
Abstract Epigenetic clocks derived from DNA methylation robustly predict biological aging, health, and mortality, yet differ substantially in their predictive profiles. The biological processes underlying these differences remain poorly understood. Using data from 3227 participants in the U.S. Health and Retirement Study, with contemporaneous DNA methylation and RNA-sequencing, we examined the five most widely used epigenetic clocks (Horvath, Hannum, PhenoAge, GrimAge, and DunedinPACE).
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