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Haruhito Sahara

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Articles

Mesothelial cells promote peritoneal invasion and metastasis of ascites-derived ovarian cancer cells through spheroid formation

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By Lixu Jin, Kaname Uno, Amy C. Pickering, Masato Yoshihara, Kazuhisa Kitami, Shohei Iyoshi, Mai Sugiyama, Yoshihiro Koya, Satoshi Nomura, Kazumasa Mogi, Emiri Miyamoto, Hiroki Fujimoto, Kosuke Yoshida, Satoshi Tamauchi, Yoshihiko Yamakita, Tomihiro Kanayama, Haruhito Sahara, Akira Yok
| Science Magazine Verified
Abstract Patients with epithelial ovarian cancer (EOC) are often diagnosed with peritoneal metastasis and ascites, the accumulation of intraperitoneal fluid containing nonmalignant cells. However, the interactions between EOC and nonmalignant cells before peritoneal metastasis remain unclear. To investigate this, whole EOC spheroids were observed using a multiphoton microscope, and their invasion ability was assessed.
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