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Abstract Introduction: Dendritic cells (DCs) are pivotal orchestrators of immune activation, serving as professional antigen-presenting cells that bridge innate and adaptive immunity. Among them, conventional type 1 dendritic cells (cDC1s) play a critical role in initiating cytotoxic T-cell responses and anti-tumor immunity. Despite their therapeutic promise, the clinical translation of cDC1-based vaccines has been limited by challenges in large-scale in vitro generation.
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