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Harwell Scientifics

As seen in: The Lancet
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Articles

King George III and porphyria: an elemental hypothesis and investigation

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By Timothy Cox, Simon Lofthouse, Nicola Jack, Harwell Scientifics
| The Lancet Verified
Summary In 1969 it was proposed that the episodic madness suffered by King George III (1738–1820) resulted from an acute hereditary porphyria, variegate porphyria, caused by deficiency of protoporphyrinogen oxidase. The diagnosis was based on the historical archive and a contentious claim that living members of the House of Hanover were affected with the condition.
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