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Hasan Ali Alsailawi on Muck Rack

Hasan Ali Alsailawi

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Nanoformulated fingolimod attenuates NLRP3 inflammasome activation and promotes functional recovery in a rat model of spinal cord injury - Spinal Cord

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By Reem S. Alazragi, Siba Mekaael yaseen, Uday Abdul-Reda Hussein, Mustafa Mudhafar, Hasan Ali Alsailawi, Mohammed Hussein M. Alsharbaty
| Nature Verified
Abstract Animal study. The NLRP3 inflammasome is a key mediator in secondary cascade of spinal cord injury (SCI), making it a potential therapeutic target. This study aimed to develop a nanoformulated version of fingolimod and investigate its effects on neuroinflammation, NLRP3 inflammasome activity, glial activation, lesion volume, and functional outcomes in a rat model of moderate contusive SCI. Experimental animal research laboratory, AlSafwa University College, Karbala, Iraq.
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