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Hasan Tolga Çelik on Muck Rack

Hasan Tolga Çelik

As seen in: Nature
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Articles

Brønsted-basic small molecules activate GTP hydrolysis in KRAS-Q61 mutants

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By Ye-Cheng Wang, Si-Cong Chen, Yang Cao, Yang Wu, Celine Wang, Michael A. Norinskiy, Hasan Tolga Çelik, Ziyang Zhang, Zhongda Shi
| Nature Verified
Abstract The RAS family of oncogenes (KRAS, HRAS, NRAS) is among the most frequently mutated genes in human cancer. Therapeutic development has largely focused on inhibitors for KRAS codon 12 mutations, while mutant-selective inhibitors for Q61 variants remain elusive. A common mechanistic feature of G12 and Q61 mutants is the reduced efficiency of GTP hydrolysis, which enriches RAS in its active, signaling-competent state.
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Development and validation of machine learning-based clinical decision support tool for identifying malnutrition in NICU patients - Scientific Reports

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By Nadir Yalçın, Hasan Tolga Çelik, Kutay Demirkan, Sule Yigit, Merve Kaşıkcı
| Nature Verified
We performed a single-center, observational cohort study including 412 NICU patients with 11 common diseases. The study’s results demonstrate that the presence of weight gain was predicted at discharge with the RF model and discharge weight gain with an elastic net model. We also developed and upgraded a tool for identifying nutritional risk in NICU patients based on the NNST.
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The effect of hyperbilirubinemia on motor repertoire of infants between 3 and 5 months of age

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By Hasan Tolga Çelik, Akmer Mutlu, Aysu Kahraman, Halil Alkan
| link.springer.com
Abstract Jaundice is a common problem and occurs as a result of the increase in bilirubin level in infants. Infants may be adversely affected by this situation. The aim of this study is to determine whether neonatal jaundice affects the movements and postures of 3- to 5-month-old infants with hyperbilirubinemia and the correlation of motor repertoire at the same age with bilirubin levels.
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