Haseli Mashhadi

ECG data collected by IMPC contributing centers (data release, DR, 15.0) were available from 26,706 wildtype control mice, stratified as presented in Table 1 and summarized below. All the mice were from a C57BL/6N-inbred substrain. ECG was performed on conscious mice, or mice anesthetized with either isoflurane or tribromoethanol.

Abstract Clinical presentation of congenital heart disease is heterogeneous, making identification of the disease-causing genes and their genetic pathways and mechanisms of action challenging. By using in vivo electrocardiography, transthoracic echocardiography and microcomputed tomography imaging to screen 3,894 single-gene-null mouse lines for structural and functional cardiac abnormalities, here we identify 705 lines with cardiac arrhythmia, myocardial hypertrophy and/or ventricular dilation.