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Hasib Aamir Riaz on Muck Rack

Hasib Aamir Riaz

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Endosome maturation is orchestrated by inside-out proton signaling through a Na + /H + exchanger and pH-dependent Rab GTPase cycling

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By Youjin Lee, Qing Ouyang, Li Ma, Michael Schmidt, Jeffrey Dupree, Anupam K. Mondal, Priyesh Mohanty, Jeetain Mittal, Oliver Beckstein, David G. Lambright, Eric Morrow Verified, Morgan Fleishman, Hasib Aamir Riaz
| Nature Verified
Abstract Endosome maturation requires lumen acidification. Is progressive lumen acidification sensed by cytosolic-side molecules driving maturation? We show here that proton efflux through the endosomal Na⁺/H⁺ Exchanger (NHE6) activates the late endosome master regulator Rab7. Importantly, NHE6 is mutated in the childhood neurologic disorder Christianson Syndrome. We demonstrate that NHE6 interacts with the Rab7 GTPase-activating protein (GAP) TBC1D5 in a complex with Rab7 on the late endosome.
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