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Hatice Zeynep Nenseth on Muck Rack

Hatice Zeynep Nenseth

As seen in: Nature
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Articles

IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling

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By Xia Sheng, Hatice Zeynep Nenseth, Su Qu, Omer F. Kuzu
| Nature Verified
Abstract Activation of endoplasmic reticulum (ER) stress/the unfolded protein response (UPR) has been linked to cancer, but the molecular mechanisms are poorly understood and there is a paucity of reagents to translate this for cancer therapy. Here, we report that an IRE1α RNase-specific inhibitor, MKC8866, strongly inhibits prostate cancer (PCa) tumor growth as monotherapy in multiple preclinical models in mice and shows synergistic antitumor effects with current PCa drugs.
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