Hayley Dunbar
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Human gut bacteria as potent class I histone deacetylase inhibitors in vitro through production of butyric acid and valeric acid
Overexpression of histone deacetylase (HDAC) isoforms has been implicated in a variety of disease pathologies, from cancer and colitis to cardiovascular disease and neurodegeneration, thus HDAC inhibitors have a long history as therapeutic targets. The gut microbiota can influence HDAC activity via microbial-derived metabolites.
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