Citation: Mousa A, Cuomo-Dannenburg G, Thompson HA, Chico RM, Beshir KB, Sutherland CJ, et al. (2024) Measuring protective efficacy and quantifying the impact of drug resistance: A novel malaria chemoprevention trial design and methodology. PLoS Med 21(5): e1004376. https://doi.org/10.1371/journal.pmed.1004376 Academic Editor: Peter MacPherson, University of Glasgow, UNITED KINGDOM Received: September 8, 2023; Accepted: March 14, 2024; Published: May 9, 2024 Copyright: © 2024 Mousa et al.