Hayma Hammoud on Muck Rack

Hayma Hammoud

As seen in: Frontiers in Immunology
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Articles

GABA A receptor agonists modulate intracellular Ca 2+ levels in activated human CD4 + T cells

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By Sergiy V. Korol, Zhe Jin, Amol K. Bhandage, Hayma Hammoud, Bryndis Birnir
| Frontiers in Immunology
Abstract GABA binding to GABAA receptors induces transient elevation in intracellular Ca2+ concentrations in activated human CD4+ T cells. Here we examined the Ca2+ response evoked by the GABAA receptor agonists THIP, muscimol, isoguvacine, and TACA and further, effects of KV1.3 and KCa3.1 channel blockers on the GABA-evoked Ca2+ signal.
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GABA, glucose and insulin orchestrate CD4+ T cells effector functions

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By Zhe Jin, Amol K. Bhandage, Sergiy V. Korol, Hayma Hammoud
| biorxiv.org
Abstract Metabolic programs of immune cells are closely linked to their effector functions. Physiological molecules including glucose, insulin and γ-aminobutyric acid (GABA) provide environmental cues and guidance, although how they coordinate to regulate the cells is still being unraveled.
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