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Hayssam Soueidan on Muck Rack

Hayssam Soueidan

As seen in: Color Research & Application
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Articles

MYB-GATA1 fusion promotes basophilic leukaemia: involvement of IL33 and nerve growth factor receptors

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By Marie-Céline Deau, Michel Arock, François-Xavier Mahon, Eric Lippert, Stéphane Ducassou, Valérie Prouzet-Mauléon, Bruno Cardinaud, Hayssam Soueidan, Cathy Quelen, Pierre Brousset, Jean-Max Pasquet, François Moreau-Gaudry
| Color Research & Application Verified
Acute basophilic leukaemia (ABL) is a rare subtype of acute myeloblastic leukaemia. We previously described a recurrent t(X;6)(p11;q23) translocation generating a MYB-GATA1 fusion gene in male infants with ABL. To better understand its role, the chimeric MYB-GATA1 transcription factor was expressed in CD34-positive hematopoietic progenitors which were transplanted into immunodeficient mice.
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