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Direct observation of the external force mediated conformational dynamics of an IHF bound Holliday junction

Aug 21, 2017 |

By Subhas C. Bera, HBNI Mumbai, Tapas Paul, Padmaja P Mishra

| Royal Society of Chemistry

We have investigated the isomerization dynamics and plausible energy landscape of 4-way Holliday junctions (4WHJs) bound to integration host factor (IHF, a DNA binding protein), considering the effect of applied external force, by single-molecule FRET methods.

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Direct observation of the external force mediated conformational dynamics of an IHF bound Holliday junction

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