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Initial continuous renal replacement therapy after stage 3 acute kidney injury without urgent dialysis indications in critically ill adults
Abstract Whether continuous renal replacement therapy (CRRT) should be routinely initiated soon after severe acute kidney injury (AKI) in critically ill adults without urgent dialysis indications remains uncertain. We emulated a target trial using MIMIC-IV among adults in their first ICU stay who newly reached KDIGO stage 3 AKI by creatinine or urine-output criteria, had no prespecified urgent dialysis indication at time zero, and remained alive and in the ICU at 24 h.
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