Hee Young Kwon

Abstract Frustrated magnetic systems such as spin ice are key platforms for novel metamaterials. However, identifying their ground states in finite arrays is a formidable challenge, as boundary sensitivity and metastable states trap conventional optimization methods. We introduce a virtuous-cycle AI pipeline where a genetic algorithm explores the latent space of a variational autoencoder (VAE), with the best candidates progressively refining the VAE’s representation.

Though piperazine derivative BK10007S was known to induce apoptosis in pancreatic cancer xenograft model as a T-type CaV3.1 a1G isoform calcium channel blocker, its underlying antitumor mechanism still remains unclear so far. Thus, in the present study, the antitumor mechanism of BK10007S was elucidated in hepatocellular carcinoma cells (HCCs).