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Heebok Lee

As seen in: BioRxiv
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Articles

Temporal Phosphoproteomic Network Reconstruction of Condition-Dependent EGFR Signaling Routes Through Unmeasured Proteins

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By Gihoon Lee, Heebok Lee
| BioRxiv
Abstract Time-resolved phosphoproteomics captures fast signaling dynamics, but proteins that show no phosphorylation change, or escape detection, leave gaps the data cannot bridge. TS-BFS-BS uses the temporal order of a phosphoproteomic time course to guide a beam-pruned breadth-first search over STRING v12.5 functional, physical, and regulatory priors, returning temporally continuous routes that can pass through unmeasured bridge proteins.
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