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Abstract The entorhinal cortex is a critical brain area for memory formation, while also the region exhibiting the earliest histological and functional alterations in Alzheimer’s disease (AD). The entorhinal cortex therefore has been long hypothesized as one of the originating brain areas of AD pathophysiology, although circuit mechanisms causing its selective vulnerability remain poorly understood.
Abstract The ability to learn novel items depends on brain functions that store information about items classified by their associated meanings and outcomes1,2,3,4, but the underlying neural circuit mechanisms of this process remain poorly understood. Here we show that deep layers of the lateral entorhinal cortex (LEC) contain two groups of ‘item–outcome neurons’: one developing activity for rewarded items during learning, and another for punished items.
Highlights • Remapping of place and grid cells was investigated in APP knockin mice • Place cells were mildly deteriorated but showed severely disrupted remapping • Grid cells were severely impaired, leaving few neurons with the ability to remap • Disruption of grid cells, but not place cells, emerged in younger APP knockin mice Summary Patients with Alzheimer's disease (AD) suffer from spatial memory impairment and wandering behavior, but the brain circuit mechanisms causing such symptoms...
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