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The Complete Assessment of Small Molecule and Peptidomimetic Inhibitors of Sortase A Towards Antivirulence Treatment
This review covers the most recent advances in the development of inhibitors for the bacterial enzyme sortase A (SrtA). Sortase A (SrtA) is a critical virulence factor present ubiquitously in Gram-positive bacteria of which many are considered pathogenic. Sortases are key enzymes regulating bacterial adherence to host cells, by anchoring extracellular matrix-binding proteins to the bacterial outer cell wall.
Substrate-derived Sortase A Inhibitors: Targeting an Essential Virulence Factor of Gram-positive Pathogenic Bacteria
Substrate-derived Sortase A Inhibitors: Targeting an Essential Virulence Factor of Gram-positive Pathogenic Bacteria Helal Abujubara, Jordi C. J. Hintzen, Shadi Rahimi, Ivan Mijakovic, Daniel Tietze and Alesia A. Tietze Abstract The bacterial transpeptidase Sortase A (SrtA) is a surface enzyme of gram-positive pathogenic bacteria. It has been shown to be an essential virulence factor for the establishment of various bacterial infections, including septic arthritis.
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