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Helen Barnett on Muck Rack

Helen Barnett

  • Writer, Content Strategist and Editor, Freelance
London
As seen in: MSN UK, Wiley Online Library, Daily Express, Daily Star (UK), SAGE Publishing, OK! Magazine (UK), Echo (Essex), Professional Adviser, Maldon & Burnham Standard, Harwich and Manningtree Standard and
Content strategist/writer/journalist/editor. Formerly @Daily_Express online associate editor and award-winning crime reporter.
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Articles

Integrating Preclinical Insights for Adaptive Dose Escalation in Phase I Oncology Trials

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By Helen Barnett, Melanie Guhl, Fulvio Di Stefano
| Wiley Online Library Verified
Pavel Mozgunov and Marie-Karelle Riviere contributed equally to this study. H.Barnett, M.Guhl, F.Di Stefano, et al., “Integrating Preclinical Insights for Adaptive Dose Escalation in Phase I Oncology Trials,” Pharmaceutical Statistics25, no. 3 (2026): e70093, https://doi.org/10.1002/pst.70093. Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement Data sharing not applicable to this article as no datasets were generated or analysed during the current study.
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Joint time-to-event partial order continual reassessment method and Joint time-to-event Bayesian logistic regression model: Statistical designs for dual agent phase I/II dose finding studies with late-onset toxicity and activity outcomes - Helen Barnett,

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By Helen Barnett, Oliver Boix, Thomas Jaki, Dimitris Kontos
| SAGE Publishing
Abstract Dual agent dose-finding trials study the effect of a combination of more than one agent, where the objective is to find the Maximum Tolerated Dose Combination, the combination of doses of the two agents that is associated with a pre-specified risk of being unsafe. In a Phase I/II setting, the objective is to find a dose combination that is both safe and active, the Optimal Biological Dose, that optimises a criterion based on both safety and activity.
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How to add baskets to an ongoing basket trial with information borrowing

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By Libby Daniells, Pavel Mozgunov, Helen Barnett, Alun W. Bedding
| SAGE Publishing
1. Introduction Basket trials are a form of master protocol in which a single treatment is administered to patients across different disease types, all of whom possess the same genetic aberration.
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