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Helen Hilton

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Digging deeper into pain - an ethological behavior assay correlating well-being in mice with human pain experience.

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By Luke A. Pattison, Sampurna Chakrabarti, Helen Hilton, Alex Cloake
| biorxiv.org
Abstract The pressing need for safer, more efficacious analgesics is felt worldwide. Pre–clinical tests in animal models of painful conditions represent one of the earliest checkpoints novel therapeutics must negotiate before consideration for human use. Traditionally, the pain status of laboratory animals has been inferred from evoked nociceptive assays which measure their responses to noxious stimuli.
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Inhibition of sensory neuron driven acute, inflammatory, and neuropathic pain using a humanised chemogenetic system

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By Jimena Sánchez, Steven Middleton, Luke A. Pattison, Helen Hilton
| biorxiv.org
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