Helena Wallin

European managers have signed a landmark Pledge backing the target of a 90% reduction in emissions by 2040. Yet, they are urging the EU to involve them in shaping a realistic and pragmatic industrial transition plan - one that moves beyond the rigidity and ideology that have often characterized the Green Deal. Approved in October 2025 by CEC European Managers, the Pledge - “A Vision for European Climate Leadership” - represents the collective voice of one million managers across the continent.

Introduction Neurotrophic factors are important for neuroplasticity throughout the central and peripheral nervous system and brain-derived neurotrophic factor (BDNF) specifically is known to be essential for brain health (Binder & Scharfman, 2004; Kowiański et al., 2018; Wang et al., 2022).

Materials and methods The current study population is part of the PROGRESS 2002 study, a single-center, prospective observational cohort study conducted at Karolinska University Hospital in Stockholm, Sweden. Cross-sectional and longitudinal analyses were performed [4, 20–22]. Subjects who provided blood samples for TRP, KYN and KYNA analyses and who were scheduled for exercise tests were included. Blood sampling and exercise tests were conducted at the most a few days apart.