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Articles by Hellyeh Hamidi
Signaling downstream of tumor–stroma interaction regulates mucinous colorectal adenocarcinoma apicobasal polarity
Abstract Mucinous colorectal carcinoma (MUC CRC) metastasis to multiple organs, and to the peritoneum, is associated with poor prognosis. Disseminating MUC CRCs exhibit either conventional (apical-in) or inverted (apical-out) polarity that influence patient outcomes. Therefore, it is critical to identify how MUC CRC polarity is regulated. Here, we analyze patient-derived MUC CRC xenografts with either apical-in or apical-out polarity.
Restoring the tumour mechanophenotype of vocal fold cancer reverts its malignant properties - Nature Materials
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Abstract Increased extracellular matrix deposition and stiffness promotes solid tumour progression. Yet, the precise mechanotransduction pathways, especially in less-studied mechanically responsive cancers, remain poorly understood. Here we address this gap using patient-derived tumour cells from early (mobile, T1) and advanced (immobile, T3) stages of vocal fold cancer, the most common squamous cell carcinoma severely impacting the voice box.
By Jasmin Kaivola, Karolina Punovuori, Megan R. Chastney, Hind Abdo, Gautier Follain, Omkar Joshi, Yekaterina A. Miroshnikova, Fabian Krautgasser, Jasmin Di Franco, James Conway, Sofia Held, Fabien Bertillot, Jaana Hagström, Antti Mäkitie, Heikki Irjala, Sami Ventelä, Hellyeh Hamidi, Giorgio Scita, Roberto Cerbino, Sara A. Wickström, Johanna Ivaska, Mathilde Mathieu
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Nature
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Signaling downstream of tumor-stroma interaction regulates mucinous colorectal adenocarcinoma apicobasal polarity
Abstract Mucinous colorectal carcinoma (MUC CRC) dissemination into the tumor stroma and metastasis to multiple organs, including the peritoneum, is associated with poor prognosis. Disseminating MUC CRCs exhibit either a conventional apical-in or an inverted apical-out polarity phenotype that influence patient outcome. Identifying the mechanisms controlling MUC CRC polarity is critical to understand disease progression.
SHANK3 depletion leads to ERK signalling overdose and cell death in KRAS-mutant cancers - Nature Communications
Abstract The KRAS oncogene drives many common and highly fatal malignancies. These include pancreatic, lung, and colorectal cancer, where various activating KRAS mutations have made the development of KRAS inhibitors difficult.
Author Correction: Every step of the way: integrins in cancer progression and metastasis
Nature Reviews Cancer (2018) https://doi.org/10.1038/s41568-018-0038-z Published online 12 July 2018 In the originally published article, pertuzumab was incorrectly described as an anti-PI3K therapy in the section ‘Integrins in anticancer therapy’.
Integrin trafficking in cells and tissues
Abstract Cell adhesion to the extracellular matrix is fundamental to metazoan multicellularity and is accomplished primarily through the integrin family of cell-surface receptors. Integrins are internalized and enter the endocytic–exocytic pathway before being recycled back to the plasma membrane. The trafficking of this extensive protein family is regulated in multiple context-dependent ways to modulate integrin function in the cell.
Every step of the way: integrins in cancer progression and metastasis
1.Humphries, J. D., Byron, A. & Humphries, M. J. Integrin ligands at a glance. J. Cell Sci. 119, 3901–3903 (2006).2.Arruda Macêdo, J. K., Fox, J. W. & de Souza Castro, M. Disintegrins from snake venoms and their applications in cancer research and therapy. Curr. Protein Pept. Sci. 16, 532–548 (2015).3.Hussein, H. A. M. et al. Beyond RGD: virus interactions with integrins. Arch. Virol. 160, 2669–2681 (2015).4.De Franceschi, N., Hamidi, H., Alanko, J., Sahgal, P. & Ivaska, J. Integrin traffic — the update. J. Cell Sci.
Cell-derived matrices for studying cell proliferation and directional migration in a complex 3D microenvironment
Cellular interaction with the surrounding extracellular matrix (ECM) regulates almost every facet of tissue homeostasis by providing important survival, growth and differentiation cues to cells within tissues. Historically, the vast majority of investigations focused on cell biology have been performed in rigid 2D cell culture conditions that lack many features of the in vivo cellular environment.
The complexity of integrins in cancer and new scopes for therapeutic targeting
Cancer is a complex disease and progresses within a dynamically evolving extracellular matrix that controls virtually every aspect of the tumour and tumour-associated cells. Interactions with the extracellular microenvironment are predominately mediated by a family of cell-surface transmembrane receptors called integrins.
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