Hematologic Diseases Laboratory

Conflicts of Interest The authors declare no conflicts of interest. Supporting Information Filename Description ajh27558-sup-0001-Supinfo.docxWord 2007 document , 67.6 KB Data S1 Supporting Information. References 1 and , “Congenital Hemolytic Anemia,” Medical Clinics of North America 101, no. 2 (2017): 361–374. 2, , , et al., “Prevalence of Congenital Hemolytic Disorders in Denmark, 2000-2016,” Clinical Epidemiology 12 (2020): 485–495.

ORIGINAL ARTICLE Ming-Zhu Jia and Wei-Jing Li contributed equally to this work. Abstract Introduction Relapse remained the major obstacle to improving the prognosis of children with acute lymphoblastic leukemia (ALL). This study aimed to investigate the changing patterns of Ig/TCR gene rearrangements between diagnosis and relapse and the clinical relevance and to explore the mechanism of leukemic relapse.